ABSTRACT
Systemic lupus erythematosus (SLE) is an autoimmune disorder that mainly affects reproductive age group women. Pregnancy may worsen SLE; especially, is associated with nephritis and SLE may lead to various pregnancy complications. Here, we present a series of eight known cases of pregnant women with SLE nephritis; of which 6 were booked and 2 cases were unbooked. Histological grading of renal involvement of the patients was done according to the World Health Organization classification/2004 classification of International Society of Nephrology/Renal Pathology Society. SLE activity in each patient was assessed using SLE disease activity index-2K. All cases were followed up to delivery and 12 months thereafter. It was found that the booked cases who conceived during disease remission had favorable outcomes, whereas, the unbooked cases had a disease flare during pregnancy leading to poor outcomes. Pregnancy should only be attempted after proper planning and disease remission in patients with SLE.
ABSTRACT
The study was undertaken to determine the sialic acid concentration of cervical tissue and serum of women with healthy and unhealthy cervix. The sialic acid value in local tissue of cervix and in serum showed slight elevation in benign inflammatory lesions, moderate elevation was found in severe dysplasia and preinvasive carcinoma and marked elevation in invasive carcinoma cervix. The values, both in the serum and in the cervical tissue, increased gradually with the advancement of grading of frank malignancy. The elevation of sialic acid in the serum was slow to start with but persisted for a longer period, wereas the concentration in local tissue was found to be increasing with the pathological process.